Publications

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Journal of Structural Biology. 169(3), 294-303

Structures of two elapid snake venom metalloproteases with distinct activities highlight the disulfide patterns in the D domain of ADAMalysin family proteins.
Guan HH, Goh KS, Davamani F, Wu PL, Huang YW, Jeyakanthan J, Wu WG, Chen CJ. (2010)
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Molecular & Cellular Proteomics. 8(9), 2034-50

Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2.
Ku, W. C., Chiu S. K., Chen, Y. J., Huang, H. H., Wu, W., and Chen, Y. J. (2009)
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Chemphyschem. 10, 549-558.

Fluorescence Single-Molecule Study of Cobra Phospholipase A(2) Action on a Supported Gel-Phase Lipid Bilayer.
Chiu C. R., Huang W. N., Wu W., Yang T. S. (2009)
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Biochemistry 46, 12111-12123

Role of Glycosphingolipid conformational change in membrane pore forming activity of Cobra cardiotoxin.
Tjong, S. C., Wu, P. L., Wang C. M., Huang, W. N., Ho, N. L., and Wu, W. (2007)

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Biochemistry 46, 9941-9952

Structures of heparin-derived tetrasaccharide bound to cobra cardiotoxins: heparin binding at a single protein site with diverse side chain interactions.
Tjong, S.C., Chen, T.S., Huang, W.N., and Wu, W. (2007)

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J.Mol. Biol. 367, 456-472

PWWP module of human Hepatoma-derived growth factor forms a domain-swapped dimer with much higher affinity for heparin.
Sue, S.C., Lee, W.T., Tien, S.C., Lee, S.C., Yu, J.G., Wu, W.J., Wu, W., and Huang, T.H. (2007)
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J. Biol. Chem. 281, 7937-7945.

Non-cytotoxic cobra cardiotoxin A5 binds to integrin αv β3 and inhibits bone resorption: Identification of cardiotoxins as non-RGD integrin- binding proteins of the Ly-6 family
Wu, P.L., Lee, S.C., Chuang, C.C., Mori, S., Akakura, N., Wu, W., and Takada, Y. (2006)

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J. Biol. Chem. 281, 656-667

Glycosphingolipid-facilitated membrane insertion and internalization of cobra cardiotoxin: The sulfatide/ cardiotoxin complex structure in a membrane-like environment suggests a lipid-dependent cell-penetrating mechanism for membenae binding polypetides.
Wang, C.H., Liu, J.H., Lee, S.C., Hsiao, C.D., and Wu, W. (2006)

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Toxicon 46, 430-40

Cobra cardiotoxin-induced cell death in fetal rat cardiomyocytes and cortical neurons: different pathway but similar cell surface target.
Wang, C.H., Monette, R., Lee, S.C., Morley, P., and Wu, W. (2005)
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FEBS Lett. 579,3169-74.

Amphiphilic beta-sheet cobra cardiotoxin targets mitochondria and disrupts its network. FEBS Lett.
Wang, C.H., and Wu, W. (2005)
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Biochemistry 44, 7414-26

Structural difference between group I and group II cobra cardiotoxins: X-ray, NMR, and CD analysis of the effect of cis-proline conformation on three-fingered toxins.
Chen, T.S., Chung, F.Y., Tjong, S.C., Goh, K.S., Huang, W.N., Chien, K.Y., Wu, P.L., Lin, H.C., Chen, C.J., and Wu, W. (2005)
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Carbohydr. Res. 340, 355-372

Development of specific inhibitors for heparin-binding proteins based on the cobra cardiotoxin structure: an effective synthetic strategy for rationally modified heparin-like disaccharides and a trisaccharide.
Ke, W., Whitfield, D.M., Brisson, J.R., Enright, G., Jarrell, H.C., and Wu, W. (2005)
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J. Biol. Chem. 280, 9567-9577

Structural basis of citrate-dependent and heparan sulfate-mediated cell surface retention of cobra cardiotoxin A3.
Lee, S.C., Guan, H.H., Wang, C.H., Huang, W.N., Tjong, S.C., Chen, C.J., and Wu, W. (2005)
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J. Mol. Biol. 343, 1365-1377

Solution structure and heparin interaction of human hepatoma-derived growth factor.
Sue, S.C., Chen, J.Y. Lee, S.C., Wu, W., and Huang, T.H. (2004)

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Acta Crystallogr. D Biol. Crystallogr. 60, 1912-1915.

Purification, crystallization and preliminary X-ray crystallographic analysis of a cysteine-rich secretory protein (CRISP) from Naja atra venom.
Wang, Y.L., Goh, K.X., Wu, W., and Chen, C.J. (2004)
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NMR of Glyco-Conjugates, edited by J.Jimenez-Barbero, et al, Wiley-VCH, Weinhem.

NMR of carbohydrates: 1D homonuclear selective methods.
Brisson, J.R., Sue, S.C., Wu, W.G., McManus, G., Nghia, P.T., and Uhrin, D. (2002)
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Proteins: Membrane Binding and Pore Formation, edited by G. Anderluh, et al, Landes Biosciences, Austin.　

Role of Heparan Sulfate and Glycosphingolipid in the Pore Formation of Basic polypeptides of Cobra Cardiotoxin. 
Wu, W.G., Tjong, S.C., Wu, P.L., Kuo, J.H., and Karen, Wu. (2009)