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Research Interest:
Our research interest focuses on how gene expression changes affect phenotypes in a living organism, especially stress response and lifespan extension and recently extending to neurodegeneration and cancer.Longevity organisms usually possess better resistance to a variety of stresses.To better and efficiently identify longevity genes, we use molecular approach and genetic tools to isolate genes or mutants in response to different stresses.By using the multiple stress strategy on both forward and reverse genetic screens, we have isolated several mutants or genes to provide longevity and stress resistance in Drosophila melanogaster.Several longevity strains have been characterized and identified the target genes.We have found the identified longevity related genes not only extending lifespan but also preventing neurodegeneration and cancer proliferation.We are using different model systems and in collaboration with the different fields of experts to answer the questions raised from our research.The goal is to identify the longevity genes and their pathways and mechanisms for the development of therapeutic agents to treat aging related diseases, like cancer, neurodegeneration, and cardiovascular diseases. It will help to relieve the burden of the medicare expenses in the inevitably growing worldwide aging society, and will enlighten how to live healthy and vigorous longevity.
Honors:
2010 Outstanding Publication Award, NTHU
2010 Outstanding Thesis Award, College of Life Science, NTHU.
2009 Outstanding Research Award, College of Life Science, NTHU
2008 Outstanding Teaching Award, College of Life Science, NTHU
2000-2003 Postdoctoral Research Fellowship, National Institute of Aging, NIH.
2000 Postdoctoral Fellowship, John Douglas French Alzheimerˇ¦s Foundation.
1996-1997 PhRMA Fellowship, Pharmaceutical Research and Manufactures of America Foundation. ( USA national-wide competition award)
1996-1997 Charles & Charlotte Krown Fellowship, School of Pharmacy, USC.
Selected Publications: (*corresponding author)
- Ti-Chun Chao, Wen-Chi Su, Jing-Ying Huang, Yung-Chia Chen, King-Song Jeng, Horng-Dar Wang, and Michael Lai (2011) ˇ§PSTPIP2, Proline-Serine-Threonine Phosphatase Interacting Protein 2, a Host Membrane-Deforming Protein, is critical for Membranous Web Formation in Hepatitis C Virus replication.ˇ¨ Journal of Virology (accepted).
- C.-T. Wang, Y.-C. Chen, Y.-Y. Wang, M.-H. Huang, T.-L. Yen, H. Li, C.-J. Liang, T.-K. Sang, S.-C. Ciou, C.-H. Yuh, C.-Y. Wang, T. J. Brummel and H.-D. Wang* (2011) ˇ§Reduced neuronal expression of ribose-5-phosphate isomerase enhances tolerance to oxidative stress, extends lifespan, and attenuates polyglutamine toxicity in Drosophila.ˇ¨ Aging Cell in press..
- J.-W. Lu, Y. Shia, W.-Y. Yang, Y.-I. Lin, C.-C. Li, T.-F. Tsai, K.-W. Chang, G.-S. Shieh, S.-F. Tsai, H.-D. Wang, and C.-H. Yuh (2011) ˇ§Identification of the common regulators for hepatocellular carcinoma induced by hepatitis B virus X antigen in a mouse model. ˇ¨ Carcinogenesis in press.
- I.-L. Hsin, G.-T. Sheu, H.-H. Chen, L.-Y. Chiu, H.-D. Wang, H.-W. Chan, C.-P. Hsu,and J.-L. Ko (2010) N-acetyl Cysteine Mitigates Curcumin-mediated Telomerase Inhibition through Rescuing of Sp1 Reduction in A549 cells.Mutat Res. 688: 72-77.
- C.-H. Chao, H.-D. Wang, and C.-H. Yuh (2010) Complexity of Cis-regulatory Organization of Six3a during Forebrain and Eye Development in Zebrafish. BMC Dev Biol. 10: 35-
- Y.-L. Liu, W.-C. Lu, T. J. Brummel, C.-H. Yuh, P.-T. Lin, T.-Y. Kao, F.-Y. Li, P.-C. Liao, S. Benzer, and H.-D. Wang* (2009) Reduced expression of alpha-1,2-mannosidase I extends lifespan in Drosophila melanogaster and Caenorhabditis elegans. Aging Cell. 8: 370-379.
- T.-M. Chan, C.-H. Chao, H.-D. Wang,Y.-J. Yu, and Chiou-Hwa Yuh (2009).Functional Analysis of the Evolutionarily Conserved Cis-Regulatory Elements on the Sox17 Gene in Zebrafish.Developmental Biology 326: 456-470.
- T.-M. Chan, W. Longabaug, H. Bolouri, H.-L. Chen, W.-F. Tseng, C.-H. Chao, T.-H. Jang, Y.-I Lin, S.-C. Hung, H.-D. Wang, and C.-H. Yuh(2009).Developmental Gene Regulatory Networks in the Zebrafish Embryo. Biochim. Biophys. Acta-Gene Regul. Mech.1789: 279-298.
- P.-C. Liao, H.-Y. Lin, C.-H. Yuh, L.-K. Yu, and H.-D. Wang* (2008). The effect of neuronal expression of heat shock proteins 26 and 27 on lifespan, neurodegeneration and apoptosis in Drosophila. Biochem. Biophys. Res. Commun.376: 637-641.
- H.-D. Wang, P. Kazemi-Esfarjani, and S. Benzer (2004). Multiple-stress analysis for isolation of Drosophila longevity genes. Proceedings of the NationalAcademy of Science of the United States of America. 101: 12610-12615.
- S.S. Johnson, N. Mandavia, H.-D. Wang, and D.L. Johnson (2000). Transcriptional Regulation of the TATA-Binding Protein by Ras Cellular Signaling. Mol. Cell. Biol. 20 : 5000-5009.
- H.-D. Wang, A. Trivedi, and D.L. Johnson (1998). Regulation of RNA Polymerase I-Dependent Promoter by the Hepatitis B Virus X Protein via Activated Ras and TATA-binding Protein. Mol. Cell. Biol. 18 : 7086-7094.
- H.-D. Wang, A. Trivedi, and D.L. Johnson (1997). Hepatitis B Virus X Protein induces RNA Polymerase III-dependent Gene transcription and Increases Cellular TATA-Binding Protein by Activating the Ras Signaling Pathway. Mol. Cell. Biol. 17 : 6838-6846.
- H.-D. Wang, C.-H. Yuh, C.V. Dang, and D.L. Johnson (1995). The Hepatitis B Virus X Protein Increases the Cellular Level of TATA-binding Protein which Mediates Transactivation of RNA Polymerase III Genes. Mol. Cell. Biol. 15 : 6720-6728.
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