Experience　Lessons　Thesis supervision　Research interests　Projects　

Achievements　Publications　Academic honor　Public service

　Recent Publications(2008-2016)

1. Kun-Mou Li, Craig Wilkinson, Juho Kellosalo, Jia-Yin Tsai, Tommi Kajander, Lars Jeuken, Yuh-Ju Sun*, and Adrian Goldman* “Membrane pyrophosphatases from Thermotoga maritima and Vigna radiata suggest a conserved coupling mechanism” Nature Communications (2016), 7:13596
2. Ming-Yang Chang, Yi-Chuan Cheng, Shen-Hsing Hsu, Tsu-Lin Ma, Li-Fang Chou, Hsiang-Hao Hsu, Ya-Chung Tian, Yung-Chang Chen, Yuh-Ju Sun, Cheng-Chieh Hung, Rong-Long Pan and Chih-Wei Yang (2016). “Leptospiral outer membrane protein LipL32 induces inflammation and kidney injury in zebrafish larvae. ” Scientific Reports, 6:27838 | DOI: 10.1038/srep27838.
3. Vankadari Naveen, Chen-Hsi Chu, Bo-Wei Chen, Yen-Chun Tsai, Chwan-Deng Hsiao and Yuh-Ju Sun* (2016) “Helicobacter pylori cell binding factor 2: Insights into domain motion” Journal of Structural Biology 194, 90–101
4. Shen-Hsing Hsu, Yueh-Yu Lo, Tseng-Huang Liu, Yih-Jiuan Pan, Yun-Tzu Huang, Yuh-Ju Sun, Cheng-Chieh Hung, Fan-Gang Tseng, Chih-Wei Yang, and Rong-Long Pan (2015). “Substrate Induced Changes in Domains Interaction of Vacuolar H+-Pyrophosphatase” J Biol Chem. 290, 1197-1209.
5. Bo-Wei Chen, Ming-Hsing Lin, Chen-Hsi Chu, Chia-En Hsu, and Yuh-Ju Sun* (2015) “Insights into ParB spreading from the complex structure of Spo0J and parS” Proc. Natl. Acad. Sci. USA 112 (21), 6613-6618
6. Jia-Yin Tsai, Juho Kellosalo, Yuh-Ju Sun* and Adrian Goldman* (2014) “Proton/sodium pumping pyrophosphatases: the last of the primary ion pumps” Current Opinion in Structural Biology 27:38–47
7. Chu, CH, Li, KM, Lin, SW, Chang, M DT, Jiang, TY, and Sun, YJ* (2014) “Crystal Structures of Starch Binding Domain from Rhizopus oryzae Glucoamylase in Complex with Isomaltooligosaccharide: Insights into Polysaccharide Binding Mechanism of CBM21 Family” Proteins: Structure, Function, and Bioinformatics 82, 1079-1085.
8. Yu-Jung Chang, Kuan-Wei Chen, Ching-Jen Chen, Ming-Hsing Lin, Yuh-Ju Sun, Jia-Lin Lee, Ing-Ming Chiu, Linyi Chen (2014) “SH2B1b Interacts with STAT3 and Enhances Fibroblast Growth Factor 1-Induced Gene Expression during Neuronal Differentiation” Molecular and Cellular Biology V34 p. 1003–1019
9. Tsung-Fu Yu, Manuel Maestre-Reyna, Chia-Yun Ko, Tzu-Ping Ko, Yuh-Ju Sun, Tsai-Yun Lin, Jei-Fu Shaw*, Andrew H.-J. Wang (2014) “Structural Insights of the ssDNA Binding Site in the Multifunctional Endonuclease AtBFN2 from Arabidopsis thaliana” PLoS One. 9(8): e105821
10. Lin, MH, Chang, YC, Hsiao, CD, Huang, SH, Wang, MS, Ko, YC, Yang CW and Sun, YJ* (2013). “LipL41, a Hemin Binding Protein from Leptospira santarosai Serovar Shermani” PLoS One, 12;8(12):e83246
11. Huang, YT, Liu TH, Lin, SM, Chen, YW, Pan, YJ, Lee, CH, Sun, YJ, Tseng, FG, Pan, RL. (2013). Squeezing at Entrance of Proton Transport Pathway in Proton-translocating Pyrophosphatase upon Substrate Binding. J Biol Chem. 288:19312-19320.
12. Lo, YY, Hsu, SH, Ko, YC, Hung, CC, Chang, MY, Hsu, HH, Pan, MJ, Chen, YW, Lee, CH, Tseng FG, Sun, YJ, Yang, CW, Pan, RL. (2013) Essential calcium binding cluster of Leptospira LipL32 for inflammatory responses through the Toll-like receptor 2 pathway. J Biol Chem.88:12335-44
13. Lin, S.-M. Tsai, J.-Y., Hsiao, C.-D., Huang, Y.-T., Chiu, C.-L., Liu, M.-H. Tung, J.-Y., Liu, T.-H., Pan, R.-L. & Sun Y.-J.* (2012) Crystal Structure of a Membrane-embedded H+-translocating Pyrophosphatase Nature 484, 399-403.
14. Chu, Chen-His, Liu, Mu-Hsuan, Chen, Pin-Chen, Lin, Ming-Hsing, Li, Yi-Chuan, Hsiao, Chwan-Deng and Sun, Yuh-Ju* (2012) Crystal structures of Helicobacter pylori uridylate kinase: insight into the product UDP release Acta Cryst D. V.68, 773-783.
15. Chang, Y.-W., Lin, T.-W., Li, Y.-C., Huang, Y.-S., Sun, Y.-J. and Hsiao, C.-D. (2012) Interaction Surface and Topology of Get3/Get4/Get5, a Complex Involved in Targeting Tail-Anchored Proteins to the Endoplasmic Reticulum. J. Biol. Chem. 287(5):4783-89.
16. Jiang, TY, Ci, YP, Chou, WI, Lee, YC, Sun, YJ, Chou, WY, Li, KM, Chang, MD.(2012) “Two unique ligand-binding clamps of Rhizopus oryzae starch binding domain for helical structure disruption of amylose.” PLoS One. 2012;7(7):e41131
17. Lo, Y.-H., Liu, S.-W., Sun, Y.-J., Li, H.-W and Hsiao, C.-D. (2011) Mutations altering interplay of GkDnaC helicase to DNA reveal an insight into helicase function and unwinding mechanism. PLoS One. 6(12) e29016
18. Tung, J.Y., Yang, C.W., Chou, S.W., Lin, C.C. and Sun, Y.J.* (2010). Calcium Binds to LipL32, a Lipoprotein from Pathogenic Leptospira, and Modulates Fibronectin Binding. J. Biol. Chem. 285, 3245-52.
19. Hsu, S.H., Lo, Y.Y., Tung, J.Y., Ko, Y.C., Sun, Y.J., Hung, C.C., Yang, C.W., Tseng, F.G., Fu, C.C., Pan, R.L. (2010). Leptospiral outer membrane lipoprotein LipL32 binding on toll-like receptor 2 of renal cells as determined with an atomic force microscope. Biochemistry. 6;49, 5408-17.
20. Chang, Y.W., Chuang, Y.C., Ho, Y.C., Cheng, M.Y., Sun, Y.J., Hsiao, C.D., Wang, C. (2010). Crystal structure of Get4/Get5 complex and its interactions with Sgt2, Get3 and Ydj1. J. Biol. Chem. 285, 9962-70.
21. Hung, K.W., Chang Y.W., Eng, E.T., Chen, J.H., Chen, Y.C., Sun, Y.J., Hsiao, C.D., Dong, G., Spasov, K.A., Unger, V.M., Huang, T.H. (2010). Structural fold, conservation and Fe(II) binding of the intracellular domain of prokaryote FeoB. J. Struct. Biol. 170, 501-12.
22. Chan, K.W., Lee, Y.J., Wang, C.H., Huang, H.M., and Sun, Y.J. (2009). Single-Stranded DNA-Binding Protein Complex from Helicobacter pylori Suggests an ssDNA-Binding Surface. J. Mol. Biol. 388, 508-519.
23. Tsai, K.L., Lo, Y.H., Sun, Y.J., and Hsiao, C.D. (2009). Molecular Interplay between the Replicative Helicase DnaC and Its Loader Protein DnaI from Geobacillus kaustophilus. J. Mol. Biol. 393, 1056-1069.
24. Lo, Y.H., Tsai, K.L., Sun, Y.J., Chen, W.T., Huang, C.Y., and Hsiao, C.D. (2009). The crystal structure of a replicative hexameric helicase DnaC and its complex with single-stranded DNA. Nucleic Acids Res. 37, 804-814.
25. Tung, J.Y., Chang, M.D.T., Chou, W.I., Liu, Y.Y., Yeh, Y.H., Chang, F.Y., Lin, S.C., Qiu, Z.L. and Sun, Y.J.* (2008). Crystal Structures of Starch Binding Domain from Rhizopus oryzae Glucoamylase Reveal a Polysaccharide Binding Path. Biochemical Journal 416, 27-36.
26. Chu, C.H., Lai, Y.J., Huang, H., and Sun, Y.J.* (2008). Kinetic and structural properties of triosephosphate isomerase from Helicobacter pylori. Proteins 71, 396-406.
27. Chang, Y.W., Sun, Y.J., Wang, C., Hsiao, C.D. (2008). Crystal structures of the 70-kDa heat shock proteins in domain disjoining conformation. J. Biol. Chem. 283, 15502-11.